TargetMol

Buclizine dihydrochloride

Product Code:
 
TAR-T6426
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6426-50mg50mg£95.00
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TAR-T6426-100mg100mg£104.00
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TAR-T6426-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T6426-200mg200mg£115.00
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This product comes from: United States.
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Further Information

Bioactivity:
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting.
CAS:
129-74-8
Formula:
C28H35Cl3N2
Molecular Weight:
505.95
Pathway:
GPCR/G Protein; Immunology/Inflammation; Neuroscience
Purity:
0.9956
SMILES:
Cl.Cl.CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1
Target:
5-HT Receptor; AChR; Histamine Receptor

References

Mostafa GA, et al. Profiles Drug Subst Excip Relat Methodol, 2011, 36:1-33.