TargetMol

ProTx-I

Product Code:
 
TAR-TP1968
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP1968-25mg25mg£1,850.00
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Further Information

Bioactivity:
Selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels.
CAS:
484598-35-8
Formula:
C171H245N53O47S6
Molecular Weight:
3987.51
Purity:
0.98
SMILES:
0

References

Ohkubo and Yamazaki (2012) T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int.J.Oncol. 41 267 PMID: Middleton et al (2002) Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41 14734 PMID: Ohkubo et al (2010) Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2. J.Pharmacol.Sci. 112 452 PMID: