TargetMol

ω-Conotoxin GVIA

Product Code:
 
TAR-TP2062
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2062-25mg25mg£2,245.00
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Further Information

Bioactivity:
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
CAS:
106375-28-4
Formula:
C120H182N38O43S6
Molecular Weight:
3037
Purity:
0.98
SMILES:
0

References

Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431 PMID: Sato et al (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 194 1292 PMID: Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392 PMID: Connelly et al (2011) Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 667 160 PMID: