TargetMol

MK-7246

Product Code:
 
TAR-TQ0051
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0051-5mg5mg£291.00
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TAR-TQ0051-50mg50mg£1,267.00
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Quantity:
TAR-TQ0051-100mg100mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
CAS:
1218918-62-7
Formula:
C21H21FN2O4S
Molecular Weight:
416.47
Pathway:
GPCR/G Protein; Endocrinology/Hormones
Purity:
0.98
SMILES:
OC(=O)Cc1c2CC[C@H](Cn2c2ccccc12)NCS(=O)(=O)c1ccc(F)cc1
Target:
GPR

References

Gil MA, et al. Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation. Eur J Pharmacol. 2014 Nov 15;743:106-16. Gervais FG, et al. Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist. Mol Pharmacol. 2011 Jan;79(1):69-76.