TargetMol

20(S)-Hydroxycholesterol

Product Code:
 
TAR-T10085
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10085-1mg1mg£95.00
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TAR-T10085-5mg5mg£132.00
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TAR-T10085-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T10085-10mg10mg£173.00
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TAR-T10085-25mg25mg£294.00
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TAR-T10085-50mg50mg£436.00
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TAR-T10085-100mg100mg£610.00
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Further Information

Bioactivity:
20(S)-hydroxyCholesterol is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog signaling pathway with an EC50 of 3 μM in NIH3T3 cells.
CAS:
516-72-3
Formula:
C27H46O2
Molecular Weight:
402.663
Pathway:
Stem Cells
Purity:
0.98
SMILES:
[H][C@@]12CC[C@]([H])([C@@](C)(O)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Target:
Smo

References

Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20. Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.