TargetMol

CF53

Product Code:
 
TAR-T10773
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10773-1mg1mg£189.00
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TAR-T10773-5mg5mg£369.00
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TAR-T10773-1mL1 mL * 10 mM (in DMSO)£389.00
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TAR-T10773-10mg10mg£517.00
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TAR-T10773-25mg25mg£790.00
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TAR-T10773-50mg50mg£1,050.00
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Quantity:
TAR-T10773-100mg100mg£1,396.00
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This product comes from: United States.
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Further Information

Bioactivity:
CF53 is a highly potent, selective, and orally active inhibitor of BET protein (Ki: <1 nM, Kd: 2.2 nM, IC50: 2 nM for BRD4 BD1).
CAS:
1808160-52-2
Formula:
C24H25N7O2
Molecular Weight:
443.511
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21
Target:
Epigenetic Reader Domain

References

Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120.