TargetMol

DB1976

Product Code:
 
TAR-T10964
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10964-1mg1mg£229.00
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TAR-T10964-5mg5mg£389.00
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TAR-T10964-10mg10mg£544.00
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TAR-T10964-25mg25mg£830.00
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TAR-T10964-50mg50mg£1,099.00
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TAR-T10964-100mg100mg£1,460.00
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Quantity:
TAR-T10964-500mg500mg£2,850.00
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This product comes from: United States.
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Further Information

Bioactivity:
DB1976 is a selenium-thiophene analogue of DB270, a potent, cell-permeable and highly effective transcription factor PU.1 inhibitor. DB1976 strongly inhibits PU.1 binding (IC50 10 nM) and strongly inhibits PU.1 / DNA complex (DB1976-λB affinity is high, KD 12 nautical miles) in vitro. DB1976 has the effect of inducing apoptosis.
CAS:
1557397-51-9
Formula:
C20H16N8Se
Molecular Weight:
447.375
Pathway:
Apoptosis|Others
Purity:
0.98
SMILES:
NC(=N)c1ccc2nc([nH]c2c1)-c1ccc([se]1)-c1nc2ccc(cc2[nH]1)C(N)=N
Target:
Others|Apoptosis

References

Antony-Debr? I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313. Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90. Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13.