TargetMol

Mefuparib hydrochloride

Product Code:
 
TAR-T11992
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11992-50mg50mg£768.00
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TAR-T11992-100mg100mg£1,123.00
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This product comes from: United States.
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Further Information

Bioactivity:
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively.
CAS:
1449746-00-2
Formula:
C17H16ClFN2O2
Molecular Weight:
334.78
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
Cl.CNCc1ccc(cc1)-c1cc2cc(F)cc(C(N)=O)c2o1
Target:
PARP

References

1. He JX, et al. Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution. Oncotarget. 2017 Jan 17;8(3):4156-4168. 2. Nie D, et al. Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk-Shell Structure Augment Cancer Chemotherapy. Nano Lett. 2020 Feb 12;20(2):936-946.