TargetMol

ML218

Product Code:
 
TAR-T12076L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12076L-50mg50mg£677.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T12076L-100mg100mg£1,026.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel (Cav3.1, Cav3.2, Cav3.3) (IC50s: 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively). ML218 can penetrate the blood-brain barrier. ML218 has no significant inhibition of L- or N-type calcium channels, KATP, or hERG potassium channels.
CAS:
1346233-68-8
Formula:
C19H26Cl2N2O
Molecular Weight:
369.33
Pathway:
Immunology/Inflammation; Microbiology/Virology
Purity:
0.98
SMILES:
[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
Target:
CCR

References

1. Xiang Z, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742.