TargetMol

PX20606 trans racemate

Product Code:
 
TAR-T12583
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12583-5mg5mg£323.00
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TAR-T12583-50mg50mg£1,050.00
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TAR-T12583-100mg100mg£1,556.00
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Further Information

Bioactivity:
PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).
CAS:
1268244-85-4
Formula:
C29H22Cl3NO4
Molecular Weight:
554.85
Purity:
0.98
SMILES:
OC(=O)c1ccc(cc1)[C@@H]1C[C@H]1c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl

References

1. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.