TargetMol

(R)-CR8 trihydrochloride

Product Code:
 
TAR-T12617
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
CAS:
1786438-30-9
Formula:
C24H32Cl3N7O
Molecular Weight:
540.92
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
Cl.Cl.Cl.CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1
Target:
CDK

References

1. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. 2. Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13.