TargetMol

(Rac)-VU 6008667

Product Code:
 
TAR-T12679
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12679-1mg1mg£114.00
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TAR-T12679-5mg5mg£189.00
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TAR-T12679-10mg10mg£290.00
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TAR-T12679-25mg25mg£439.00
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TAR-T12679-50mg50mg£614.00
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TAR-T12679-100mg100mg£844.00
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Quantity:
TAR-T12679-500mg500mg£1,621.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50 of 1.8 μM and pIC50 of 5.75, has high CNS penetration.
CAS:
2092917-63-8
Formula:
C24H17ClF2N2O2
Molecular Weight:
438.86
Pathway:
Neuroscience|Others
Purity:
0.98
SMILES:
Cc1cc(ccc1Cl)C12N(CCN1C(=O)c1ccccc21)C(=O)c1ccc(F)c(F)c1
Target:
Others|AChR

References

1. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.