TargetMol

Dihydrexidine hydrochloride

Product Code:
 
TAR-T13463L2
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13463L2-5mg5mg£303.00
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TAR-T13463L2-50mg50mg£1,163.00
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TAR-T13463L2-100mg100mg£1,564.00
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Further Information

Bioactivity:
Dihydrexidine hydrochloride is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.
CAS:
137417-08-4
Formula:
C17H18ClNO2
Molecular Weight:
303.78
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl.[relative stereochemistry]
Target:
Dopamine Receptor

References

1. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. 2. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. 3. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42. 4. Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186(1), 25?31.