TargetMol

8-Bromo-cGMP sodium

Product Code:
 
TAR-T14064
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14064-50mg50mgEnquire
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TAR-T14064-5mg5mg£115.00
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TAR-T14064-10mg10mg£142.00
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TAR-T14064-25mg25mg£213.00
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Further Information

Bioactivity:
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium has antinociceptive effects[2]. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1].
CAS:
51116-01-9
Formula:
C10H10BrN5NaO7P
Molecular Weight:
446.086
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
[H][C@@]12COP(=O)(O[Na])O[C@@]1([H])[C@@H](O)[C@@H](O2)n1c(Br)nc2c1[nH]c(N)nc2=O
Target:
PKA

References

1. Sarkar O , et al. Nitric oxide attenuates overexpression of Gi? proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301. 2. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50.