TargetMol

CB 300919

Product Code:
 
TAR-T14879
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14879-5mg5mg£272.00
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TAR-T14879-50mg50mg£1,267.00
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Quantity:
TAR-T14879-100mg100mg£1,878.00
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This product comes from: United States.
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Further Information

Bioactivity:
CB 300919 is a quinazoline-based antitumor agent with high activity in the CH1 human ovarian tumor xenograft and has continuous exposure (96 h) growth inhibition (IC50: 2 nM).
CAS:
289715-28-2
Formula:
C32H34ClN7O2
Molecular Weight:
584.12
Purity:
0.98
SMILES:
CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4cccnc4)cc3c(=O)n2C)CC1

References

1. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-8746 2. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.