TargetMol

JND3229

Product Code:
 
TAR-T15615
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15615-1mg1mg£173.00
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TAR-T15615-5mg5mg£332.00
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TAR-T15615-1mL1 mL * 10 mM (in DMSO)£426.00
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TAR-T15615-10mg10mg£464.00
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TAR-T15615-25mg25mg£723.00
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TAR-T15615-50mg50mg£978.00
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Further Information

Bioactivity:
JND3229 is a highly potent and fourth-generation EGFRC797S reversible inhibitor (IC50: 5.8 nM). It also effectively suppressed EGFRL858R/T790M and EGFRWT (IC50: 30.5 and 6.8 nM).
CAS:
2260886-64-2
Formula:
C33H41ClN8O2
Molecular Weight:
617.2
Pathway:
Angiogenesis|JAK/STAT signaling|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CCC(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl
Target:
EGFR

References

Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.