TargetMol

L-371,257

Product Code:
 
TAR-T15682
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15682-1mg1mg£116.00
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Quantity:
TAR-T15682-5mg5mg£182.00
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TAR-T15682-10mg10mg£249.00
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TAR-T15682-25mg25mg£430.00
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TAR-T15682-50mg50mg£600.00
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Quantity:
TAR-T15682-100mg100mg£825.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.
CAS:
162042-44-6
Formula:
C28H33N3O6
Molecular Weight:
507.58
Pathway:
GPCR/G Protein; Endocrinology/Hormones
Purity:
1
SMILES:
O=C1OCC=2C=CC=CC2N1C3CCN(C(=O)C4=CC=C(OC5CCN(C(=O)C)CC5)C=C4OC)CC3
Target:
Oxytocin Receptor; Vasopressin Receptor

References

Tunstall BJ, et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 Apr 16;17(4):e2006421. Williams PD, et al. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6.