TargetMol

Ancitabine hydrochloride

Product Code:
 
TAR-T1591
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1591-100mg100mg£100.00
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TAR-T1591-200mg200mg£109.00
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TAR-T1591-1mL1 mL * 10 mM (in DMSO)£111.00
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Further Information

Bioactivity:
Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.
CAS:
10212-25-6
Formula:
C9H12ClN3O4
Molecular Weight:
261.66
Pathway:
; Cell Cycle/Checkpoint; Autophagy; DNA Damage/DNA Repair
Purity:
0.9937
SMILES:
Cl.OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O
Target:
DNA/RNA Synthesis; Autophagy

References

1. Kirsch LE, et al. J Pharm Sci, 1984, 73(7), 896-902. 2. Gray GD, et al. Biochem Pharmacol, 1972, 21(4), 465-475. 3. Lowenberg B, et al. N Engl J Med, 2011, 364(11), 1027-1036.