TargetMol

NFPS

Product Code:
 
TAR-T16292
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16292-5mg5mg£850.00
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Quantity:
TAR-T16292-50mg50mg£1,661.00
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Quantity:
TAR-T16292-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively).
CAS:
405225-21-0
Formula:
C24H24FNO3
Molecular Weight:
393.458
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
CN(CCC(Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O
Target:
Thrombin

References

1. Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93. 2. Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62.