TargetMol

R121919

Product Code:
 
TAR-T16713
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
R121919 is an effective small-molecule CRF1 receptor antagonist (Ki: 2 to 5 nM for the CRF1 receptor). It has over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.
CAS:
195055-03-9
Formula:
C22H32N6
Molecular Weight:
380.54
Purity:
0.98
SMILES:
CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C

References

1. Gutman DA, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80. 2. Post A, et al. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology (Berl). 2005 Jun;180(1):150-8.