TargetMol

SCH 546738

Product Code:
 
TAR-T16863
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16863-5mg5mg£284.00
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TAR-T16863-50mg50mg£962.00
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TAR-T16863-100mg100mg£1,324.00
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This product comes from: United States.
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Further Information

Bioactivity:
SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments.
CAS:
906805-42-3
Formula:
C23H31Cl2N7O
Molecular Weight:
492.45
Purity:
0.98
SMILES:
CC[C@H]1CN(CCN1C1CCN(Cc2ccc(Cl)cc2)CC1)c1nc(N)c(nc1Cl)C(N)=O

References

1. Jenh CH, et al. A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 2012 Jan 10;13:2. 2. Zhang X, et al. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol. 2016 Jan;64(1):160-70. 3. Yue C, et al. STAT3 in CD8