TargetMol

SHP836

Product Code:
 
TAR-T16878
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16878-5mg5mg£304.00
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TAR-T16878-50mg50mg£1,163.00
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Quantity:
TAR-T16878-100mg100mg£1,765.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).
CAS:
1957276-35-5
Formula:
C16H19Cl2N5
Molecular Weight:
352.26
Purity:
0.98
SMILES:
C[C@H]1CN(C[C@@H](C)N1)c1ncc(c(N)n1)-c1cccc(Cl)c1Cl

References

1. Liu WS, et al. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation. J Comput Aided Mol Des. 2019 Aug;33(8):759-774. 2. Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.