TargetMol

TAK-220

Product Code:
 
TAR-T16973
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16973-5mg5mg£351.00
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TAR-T16973-50mg50mg£1,267.00
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Quantity:
TAR-T16973-100mg100mg£1,669.00
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This product comes from: United States.
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Further Information

Bioactivity:
TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively).
CAS:
333994-00-6
Formula:
C31H41ClN4O3
Molecular Weight:
553.14
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.98
SMILES:
CC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(Cc2ccc(cc2)C(N)=O)CC1)c1ccc(C)c(Cl)c1
Target:
HIV Protease

References

1. Takashima K, et al. Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist. Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82. 2. Tremblay CL, et al. TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro. Antimicrob Agents Chemother. 2005 Aug;49(8):3483-5.