TargetMol

BMS 961

Product Code:
 
TAR-T22611
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22611-5mg5mg£850.00
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TAR-T22611-50mg50mg£1,661.00
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Quantity:
TAR-T22611-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMS961 is a potent and selective retinoic acid receptor gamma (RARγ) agonist (IC50: 30 nM).
CAS:
185629-22-5
Formula:
C23H26FNO4
Molecular Weight:
399.462
Purity:
0.98
SMILES:
CC1(C)CCC(C)(C)c2cc(ccc12)[C@H](O)C(=O)Nc1ccc(cc1F)C(O)=O

References

1. Gavai AV, Fink BE, Fairfax DJ, et al. Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases. J Med Chem, 2009, 52(21): 6527-6530. 2. Wong TW, Lee FY, Yu C, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res, 2006, 12(20 Pt 1): 6186-6193.