TargetMol

Fingolimod hydrochloride

Product Code:
 
TAR-T2539
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2539-50mg50mg£99.00
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TAR-T2539-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T2539-100mg100mg£111.00
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TAR-T2539-200mg200mg£134.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
CAS:
162359-56-0
Formula:
C19H34ClNO2
Molecular Weight:
343.94
Pathway:
Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel
Purity:
0.9983
SMILES:
Cl.CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
Target:
TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor

References

1. Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586. 2. Cipriani R, et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8;12:86. 3. Coldewey SM, et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9;6:27594. 4. Wallington-Beddoe CT, et al. Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia. PLoS One. 2012;7(5):e36429.