TargetMol

U-0521

Product Code:
 
TAR-T29029
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T29029-50mg50mg£664.00
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TAR-T29029-100mg100mg£962.00
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  • Further Information
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Further Information

Bioactivity:
U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain.
CAS:
5466-89-7
Formula:
C10H12O3
Molecular Weight:
180.203
Purity:
0.98
SMILES:
CC(C)C(=O)c1ccc(O)c(O)c1

References

1. Cumming P, Boyes BE, Martin WR, Adam M, Ruth TJ, McGeer EG. Altered metabolism of [18F]-6-fluorodopa in the hooded rat following inhibition of catechol-O-methyltransferase with U-0521. Biochem Pharmacol. 1987 Aug 1;36(15):2527-31. PubMed PMID: 3111485. 2. Lloyd T, Waldman CD. The antihypertensive effect of U-0521 (3',4'-dihydroxy-2-methylpropiophenone). Life Sci. 1982 Nov 8;31(19):2121-7. PubMed PMID: 7176811. 3. Reches A, Jiang D, Fahn S. Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa. Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):34-7. PubMed PMID: 7121609. 4. Henseling M. Accumulation of 3H-(-)noradrenaline in the rabbit aorta not related to uptake1 and uptake2, but sensitive to 3,4-dihydroxy-2-methylpropiophenone (U-0521) and oxytetracycline. Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):121-7. PubMed PMID: 6888566.