TargetMol

LYG-202

Product Code:
 
TAR-T36488
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36488-1mg1mg£100.00
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TAR-T36488-5mg5mg£182.00
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TAR-T36488-10mg10mg£278.00
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TAR-T36488-25mg25mg£543.00
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TAR-T36488-50mg50mg£757.00
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TAR-T36488-100mg100mg£1,002.00
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TAR-T36488-500mg500mg£1,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
LYG-202 is a synthetic flavonoid with anticancer and anti-angiogenic activities. It inhibits proliferation of HepG2, MCF-7, HeLa, BGC-823, MDA-MB-435, and HCT116 cancer cells in vitro (IC50s = 4.74-27.70 μM) via induction of apoptosis and dissipation of the mitochondrial membrane potential. LYG-202 reduces tumor growth in S180 sarcoma cell-inoculated mice. It also inhibits VEGF-stimulated human umbilical vein endothelial cells (HUVEC) cell migration and tube formation in vitro and decreases capillary sprouting in isolated rat aortic rings and the chicken chorioallantoic membrane (CAM) model of angiogenesis.
CAS:
1175077-25-4
Formula:
C25H30N2O5
Molecular Weight:
438.524
Pathway:
Apoptosis|Immunology/Inflammation
Purity:
0.98
SMILES:
COc1c(OCCCCN2CCN(C)CC2)cc(O)c2c1oc(cc2=O)-c1ccccc1
Target:
ROS|Apoptosis

References

Zeng S, et al. LYG-202, a new flavonoid with a piperazine substitution, shows antitumor effects in vivo and in vitro. Biochem Biophys Res Commun. 2009 Aug 7;385(4):551-6. Chen Y, et al. LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. J Pharmacol Sci. 2010;112(1):37-45.