TargetMol

KR-32568

Product Code:
 
TAR-T36569
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36569-1mg1mg£122.00
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TAR-T36569-1mL1 mL * 10 mM (in DMSO)£187.00
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TAR-T36569-5mg5mg£195.00
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TAR-T36569-10mg10mg£269.00
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TAR-T36569-25mg25mg£470.00
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TAR-T36569-50mg50mg£651.00
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TAR-T36569-100mg100mg£863.00
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TAR-T36569-500mg500mg£1,661.00
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Further Information

Bioactivity:
KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM). It restores cardiac contractile function ex vivo in an isolated ischemic rat heart model when used at a concentration of 10 μM. KR-32568 (0.3 mg/kg) reduces myocardial infarct size in a rat model of ischemia and reperfusion injury.
CAS:
852146-73-7
Formula:
C13H12FN3O2
Molecular Weight:
261.3
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
FC1=CC=C(C)C(C2=CC=C(C(NC(N)=N)=O)O2)=C1
Target:
Sodium Channel

References

Tang Q, et al. Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytes. Pflugers Arch. 2012;463(4):513-522. Lee S, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005;48(8):2882-2891. Hu LF, et al. Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. J Pharmacol Exp Ther. 2011;339(2):726-735. Roh HY, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005;75(1):37-44.