TargetMol

Binucleine 2

Product Code:
 
TAR-T36801
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36801-5mg5mg£850.00
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Quantity:
TAR-T36801-50mg50mg£1,661.00
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Quantity:
TAR-T36801-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.
CAS:
220088-42-6
Formula:
C13H11ClFN5
Molecular Weight:
291.71
Purity:
0.98
SMILES:
CN(C)C=Nc1c(cnn1-c1ccc(F)c(Cl)c1)C#N