TargetMol

Org 24598

Product Code:
 
TAR-T37699
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37699-5mg5mg£850.00
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Quantity:
TAR-T37699-50mg50mg£1,661.00
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Quantity:
TAR-T37699-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo.
CAS:
372198-97-5
Formula:
C19H20F3NO3
Molecular Weight:
367.368
Purity:
0.98
SMILES:
CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC(O)=O

References

Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID:11454468 Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID:12963052