TargetMol

JNJ-55308942

Product Code:
 
TAR-T37806
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37806-1mg1mg£127.00
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TAR-T37806-5mg5mg£209.00
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TAR-T37806-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T37806-10mg10mg£294.00
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TAR-T37806-25mg25mg£502.00
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TAR-T37806-50mg50mg£693.00
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Quantity:
TAR-T37806-100mg100mg£938.00
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Quantity:
TAR-T37806-500mg500mg£1,813.00
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Quantity:
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Further Information

Bioactivity:
JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectively.
CAS:
2166558-11-6
Formula:
C17H12F5N7O
Molecular Weight:
425.32
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
1
SMILES:
C[C@H]1CC=2N(N=NC2CN1C(=O)C=3C(F)=C(C(F)(F)F)N=CC3)C=4N=CC(F)=CN4
Target:
P2X Receptor

References

Bhattacharya A, et al. Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia. Neuropsychopharmacology. 2018;43(13):2586-2596. Chrovian CC, et al. A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate. J Med Chem. 2018;61(1):207-223.