TargetMol

T 26c disodium salt

Product Code:
 
TAR-T37860
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37860-5mg5mg£850.00
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Quantity:
TAR-T37860-50mg50mg£1,661.00
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Quantity:
TAR-T37860-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.
CAS:
869298-22-6
Formula:
C24H19N3Na2O6S
Molecular Weight:
523.47
Purity:
0.98
SMILES:
COC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1

References

Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810"