TargetMol

Rauwolscine hydrochloride

Product Code:
 
TAR-T4429
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4429-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4429-50mg50mg£111.00
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Further Information

Bioactivity:
Rauwolscine, a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors [1]. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki: 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50: 1.3 μM) [3]. The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior [5].
CAS:
6211-32-1
Formula:
C21H27ClN2O3
Molecular Weight:
390.91
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.999
SMILES:
Cl.COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Target:
Adrenergic Receptor

References

Neylon C B, Summers R J. [3H]?rauwolscine binding to ?2?adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species[J]. British journal of pharmacology, 1985, 85(2): 349-359. De Vos H, Czerwiec E, De Backer J P, et al. [3H] Rauwolscine behaves as an agonist for the 5-HTa receptors in human frontal cortex membranes[J]. European Journal of Pharmacology: Molecular Pharmacology, 1991, 207(1): 1-8. Cottingham C, Wang Q. ?2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapy[J]. Neuroscience & Biobehavioral Reviews, 2012, 36(10): 2214-2225. Perry B D, U'Prichard D C. [3H] Rauwolscine (?-yohimbine): a specific antagonist radioligand for brain ?2-adrenergic receptors[J]. European journal of pharmacology, 1981, 76(4): 461-464. Wainscott D B, Sasso D A, Kursar J D, et al. [3H] Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2B (5-HT2B) receptor[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1997, 357(1): 17-24.