TargetMol

L-BUTHIONINE-(S,R)-SULFOXIMINE

Product Code:
 
TAR-T5371
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5371-50mg50mg£109.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T5371-100mg100mg£139.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.
CAS:
83730-53-4
Formula:
C8H18N2O3S
Molecular Weight:
222.3
Pathway:
Apoptosis; Cell Cycle/Checkpoint;
Purity:
0.9992
SMILES:
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
Target:
Ferroptosis

References

Garza-Lomb? C, et al. Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum. Neurochem Int. 2018 Dec;121:8-18. Marengo B, et al. Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. Free Radic Biol Med. 2008 Feb 1;44(3):474-82. Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49.