TargetMol

α-Cyano-4-hydroxycinnamic acid

Product Code:
 
TAR-T7460
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7460-50mg50mg£107.00
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Quantity:
TAR-T7460-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T7460-200mg200mg£147.00
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TAR-T7460-500mg500mg£198.00
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This product comes from: United States.
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Further Information

Bioactivity:
α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
CAS:
28166-41-8
Formula:
C10H7NO3
Molecular Weight:
189.17
Pathway:
Membrane transporter/Ion channel
Purity:
0.998
SMILES:
OC(=O)C(=Cc1ccc(O)cc1)C#N
Target:
Monocarboxylate transporter

References

Colen C B , Shen Y , Ghoddoussi F , et al. Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study[J]. Neoplasia, 2011, 13(7):620-632. Miranda-Goncalves V , Honavar M , Pinheiro C , et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets[J]. Neuro-Oncology, 2013, 15(2):172-188. Tong Y, Guo C, Liu Z, et al. In situ localization of tris-(2, 3-dibromopropyl) isocyanurate in mouse organs by MALDI-IMS with auxiliary matrix strategy. Talanta. 2021: 122723.