TargetMol

Nesbuvir

Product Code:
 
TAR-TQ0090
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0090-1mg1mg£165.00
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TAR-TQ0090-5mg5mg£306.00
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TAR-TQ0090-1mL1 mL * 10 mM (in DMSO)£330.00
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TAR-TQ0090-10mg10mg£389.00
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TAR-TQ0090-25mg25mg£603.00
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TAR-TQ0090-50mg50mg£830.00
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TAR-TQ0090-100mg100mg£1,099.00
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TAR-TQ0090-500mg500mg£2,135.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Nesbuvir (HCV-796) is a nonnucleoside inhibitor of the HCV nonstructural protein 5B (NS5B) polymerase.
CAS:
691852-58-1
Formula:
C22H23FN2O5S
Molecular Weight:
446.49
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.98
SMILES:
CNC(=O)c1c(oc2cc(N(CCO)S(C)(=O)=O)c(cc12)C1CC1)-c1ccc(F)cc1
Target:
HCV Protease

References

Reich S, et al. Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem. 2010;285(18):13685-13693. Flint M, et al. Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034). Antimicrob Agents Chemother. 2009;53(2):401-411. Howe AY, et al. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrob Agents Chemother. 2008;52(9):3327-3338. Meshram RJ, et al. Effective epitope identification employing phylogenetic, mutational variability, sequence entropy, and correlated mutation analysis targeting NS5B protein of hepatitis C virus: from bioinformatics to therapeutics. J Mol Recognit. 2015;28(8):492-505. Kneteman NM, et al. HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus. Hepatology. 2009;49(3):745-752.