TargetMol

FMK

Product Code:
 
TAR-TQ0310
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0310-1mg1mg£125.00
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TAR-TQ0310-2mg2mg£148.00
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TAR-TQ0310-5mg5mg£213.00
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TAR-TQ0310-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-TQ0310-10mg10mg£325.00
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TAR-TQ0310-25mg25mg£503.00
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TAR-TQ0310-50mg50mg£695.00
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TAR-TQ0310-100mg100mg£946.00
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TAR-TQ0310-500mg500mg£1,813.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
FMK is an irreversible inhibitor of RSK2 kinase.
CAS:
821794-92-7
Formula:
C18H19FN4O2
Molecular Weight:
342.374
Pathway:
MAPK; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12
Target:
S6 Kinase

References

Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. Kang S, et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep;12(3):187-9. Cuello F, et al. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.