TargetMol

Disulfiram

Product Code:
 
TAR-T0054
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0054-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T0054-1g1g£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
CAS:
97-77-8
Formula:
C10H20N2S4
Molecular Weight:
296.52
Pathway:
Metabolism; Apoptosis; Immunology/Inflammation
Purity:
0.98
SMILES:
CCN(CC)C(=S)SSC(=S)N(CC)CC
Target:
Dehydrogenase; Interleukin; Pyroptosis

References

1. Chen D, et al. Cancer Res, 2006, 66(21), 10425-10433. 2. Wang W, et al. Int J Cancer, 2003, 104(4), 504-511. 3. Cen D, et al. J Med Chem, 2004, 47(27), 6914-6920. 4. Brar SS, et al. Mol Cancer Ther, 2004, 3(9), 1049-1060. 5. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr?8(1): 137-144. 6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.