TargetMol

Sunitinib

Product Code:
 
TAR-T0374L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0374L-100mg100mg£113.00
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TAR-T0374L-200mg200mg£136.00
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TAR-T0374L-500mg500mg£148.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sunitinib, a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
CAS:
557795-19-4
Formula:
C22H27FN4O2
Molecular Weight:
398.482
Pathway:
Autophagy; Tyrosine Kinase/Adaptors; Apoptosis; Angiogenesis; Cell Cycle/Checkpoint
Purity:
0.9967
SMILES:
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2/C(=O)Nc3ccc(F)cc23)c1C
Target:
Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy

References

1. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119. 2. Mendel DB, et al. Clin Cancer Res, 2003, 9(1), 327-337. 3. O'Farrell AM, et al. Blood, 2003, 101(9), 3597-3605. 4. Abrams TJ, et al. Mol Cancer Ther, 2003, 2(10), 1011-1021. 5. Yee KW, et al. Blood, 2004, 104(13), 4202-4209.