TargetMol

ANI-7

Product Code:
 
TAR-T10325
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10325-1mL1 mL * 10 mM (in DMSO)£102.00
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TAR-T10325-5mg5mg£122.00
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TAR-T10325-10mg10mg£172.00
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TAR-T10325-25mg25mg£254.00
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TAR-T10325-50mg50mg£378.00
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TAR-T10325-100mg100mg£531.00
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TAR-T10325-500mg500mg£1,075.00
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This product comes from: United States.
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Further Information

Bioactivity:
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM).
CAS:
931417-26-4
Formula:
C13H8Cl2N2
Molecular Weight:
263.12
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
Clc1ccc(cc1Cl)C(=Cc1ccc[nH]1)C#N
Target:
Chk

References

1. ilbert J, et al. (Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway. Mol Pharmacol. 2018 Feb;93(2):168-177. 2. Baker JR, et al. Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro. ChemMedChem. 2018 Jul 18;13(14):1447-1458. 3. Mark Tarleton, et al. Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. ?Medicinal Chemistry Communication. January 20112. (1):31-37.