TargetMol

Desformylflustrabromine hydrochloride

Product Code:
 
TAR-T11004
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11004-5mg5mg£122.00
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TAR-T11004-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T11004-10mg10mg£148.00
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TAR-T11004-25mg25mg£242.00
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TAR-T11004-50mg50mg£374.00
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TAR-T11004-100mg100mg£522.00
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Further Information

Bioactivity:
Desformylflustrabromine hydrochloride is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
CAS:
951322-11-5
Formula:
C16H22BrClN2
Molecular Weight:
357.72
Pathway:
Neuroscience
Purity:
0.98
SMILES:
Cl.CNCCc1c([nH]c2cc(Br)ccc12)C(C)(C)C=C
Target:
AChR

References

1. Nadezhda German, et al. Deconstruction of the ?4?2 Nicotinic Acetylchloine (nACh) Receptor Positive Allosteric Modulator des-Formylflustrabromine (dFBr). J Med Chem. 2011 Oct 27;54(20):7259-67. 2. Weltzin MM, et al. Desformylflustrabromine Modulates ?4?2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the ?2 Subunit. J Pharmacol Exp Ther. 2015 Aug;354(2):184-94.