TargetMol

Glutaminase-IN-1

Product Code:
 
TAR-T11421
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Glutaminase-IN-1 is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA; IC50: 1 nM). Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
CAS:
2247127-79-1
Formula:
C26H24F3N7O3Se
Molecular Weight:
618.49
Purity:
0.98
SMILES:
FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)[se]3)nn2)c1

References

1. Chen Z, et al. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2018 Dec 13.