TargetMol

Bifonazole

Product Code:
 
TAR-T1187
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1187-500mg500mg£104.00
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Quantity:
TAR-T1187-1mL1 mL * 10 mM (in DMSO)£107.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Bifonazole acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. This is vital in the cell membrane structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out.
CAS:
60628-96-8
Formula:
C22H18N2
Molecular Weight:
310.4
Pathway:
Metabolism; Microbiology/Virology
Purity:
0.9988
SMILES:
c1cn(cn1)C(c1ccccc1)c1ccc(cc1)-c1ccccc1
Target:
P45; Antibiotic; Antifungal

References

1. Zhao Y, et al. J Biol Chem,2006, 281(9), 5973-5981. 2. Cho KJ, et al. Chin J Physiol,2001, 44(3), 97-101. 3. Penso J, et al. Eur J Pharmacol,1998, 342(1), 113-117. 4. K?feler HC, et al. Br J Pharmacol. 2000 Jul;130(6):1241-6. 5. Sabzevari O, et al. Toxicology,1996, 106(1-3), 19-26.