TargetMol

LS-102

Product Code:
 
TAR-T11879
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment. LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor.
CAS:
1456891-34-1
Formula:
C24H36N8O
Molecular Weight:
452.607
Purity:
0.98
SMILES:
CCNCCN(CC)c1nc(N[C@@H](C)C2CCCCC2)nc(Nc2ccc3ncoc3c2)n1

References

1. Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6. 2. Fujita H, et al. Identification of the inhibitory activity of walnut extract on the E3 ligase Syvn1. Mol Med Rep. 2018 Dec;18(6):5701-5708.