TargetMol

RO5263397

Product Code:
 
TAR-T12745
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12745-1mg1mg£95.00
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TAR-T12745-5mg5mg£128.00
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TAR-T12745-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T12745-10mg10mg£173.00
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TAR-T12745-25mg25mg£302.00
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TAR-T12745-50mg50mg£436.00
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TAR-T12745-100mg100mg£610.00
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TAR-T12745-500mg500mg£1,219.00
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Further Information

Bioactivity:
RO5263397 is a potent, selective, and orally available agonist of TAAR1(with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively). with ntidepressant-like effect.
CAS:
1357266-05-7
Formula:
C10H11FN2O
Molecular Weight:
194.209
Purity:
0.98
SMILES:
Cc1c(F)cccc1[C@H]1COC(N)=N1

References

1. Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett.?2015 Dec 30;7(2):192-7. 2. Schwartz MD, et al. Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.Neuropsychopharmacology.?2017 May;42(6):1305-1314. 3. Espinoza S, et al. Biochemical?and?Functional?Characterization?of the?Trace?Amine-Associated?Receptor?1?(TAAR1)?Agonist?RO5263397.Front Pharmacol.?2018 Jun 21;9:645.