TargetMol

3 α-Aminocholestane

Product Code:
 
TAR-T14037
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
3α-Aminocholestane , a selective SH2 domain-containing inositol-5?-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
CAS:
2206-20-4
Formula:
C27H49N
Molecular Weight:
387.696
Pathway:
Metabolism
Purity:
0.98
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](N)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
Target:
Phosphatase

References

1. Chen Z, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61. 2. Gwenny M Fuhler, et al. Therapeutic Potential of SH2 Domain-Containing Inositol-5?-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer. Mol Med. 2012 Feb 10;18:65-75.