TargetMol

BAY 60-6583

Product Code:
 
TAR-T14506
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14506-1mg1mg£103.00
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TAR-T14506-5mg5mg£149.00
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TAR-T14506-1mL1 mL * 10 mM (in DMSO)£157.00
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TAR-T14506-10mg10mg£171.00
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TAR-T14506-25mg25mg£278.00
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TAR-T14506-50mg50mg£464.00
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TAR-T14506-100mg100mg£666.00
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TAR-T14506-500mg500mg£1,315.00
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Further Information

Bioactivity:
BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50 = 3 nM) over A1, A2A, and A3 receptors and it has a cardioprotective effect in a myocardial ischemia model[1][5]. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model[1][5].
CAS:
910487-58-0
Formula:
C19H17N5O2S
Molecular Weight:
379.44
Pathway:
GPCR/G Protein|Others|Neuroscience
Purity:
0.98
SMILES:
NC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N
Target:
Others|Adenosine Receptor

References

1. Aherne CM, et al. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis.Mucosal Immunol. 2015 Nov;8(6):1324-38. 2. Schingnitz U, et al. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury.J Immunol. 2010 May 1;184(9):5271-9. 3. Gao ZG, et al. Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Biochem Pharmacol. 2014 Aug 1;90(3):297-306. 4. Yoon Taek Oh, et al. A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation. Biomed Sci Letters 2017;23:194-200 5. John A. Auchampach, et al. Characterization of the A2B?Adenosine Receptor from Mouse, Rabbit, and Dog. J Pharmacol Exp Ther.?2009 Apr;329(1):2-13. 6. Morello S1, et al. Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells.Oncoimmunology. 2014 Feb 14;3:e27989. eCollection 2014.