TargetMol

BIP-135

Product Code:
 
TAR-T14613
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14613-1mg1mg£111.00
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TAR-T14613-2mg2mg£130.00
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TAR-T14613-5mg5mg£168.00
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TAR-T14613-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T14613-10mg10mg£229.00
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TAR-T14613-25mg25mg£383.00
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TAR-T14613-50mg50mg£536.00
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TAR-T14613-100mg100mg£736.00
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TAR-T14613-500mg500mg£1,420.00
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Further Information

Bioactivity:
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].
CAS:
941575-71-9
Formula:
C21H13BrN2O3
Molecular Weight:
421.24
Pathway:
PI3K/Akt/mTOR signaling; Stem Cells
Purity:
0.9977
SMILES:
O=C1NC(=O)C(C2=CN(C=3C=CC(Br)=CC23)C)=C1C4=COC=5C=CC=CC54
Target:
GSK-3

References

1. Chen PC, et al. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of ?7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11.