TargetMol

BMS 299897

Product Code:
 
TAR-T14673
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14673-50mg50mgEnquire
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TAR-T14673-5mg5mg£112.00
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TAR-T14673-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T14673-10mg10mg£148.00
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TAR-T14673-25mg25mg£213.00
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Further Information

Bioactivity:
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
CAS:
290315-45-6
Formula:
C24H21ClF3NO4S
Molecular Weight:
511.94
Pathway:
Neuroscience
Purity:
0.98
SMILES:
C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O
Target:
Beta Amyloid

References

1. Meunier J, et al. The ?-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates A?1-42 seeding and short-term memory deficits in the A?25-35 mouse model of Alzheimer's d 2. Weissmiller AM, et al. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.