TargetMol

Clomethiazole

Product Code:
 
TAR-T14983
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14983-100mg100mg£103.00
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TAR-T14983-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T14983-200mg200mg£117.00
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TAR-T14983-500mg500mg£148.00
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Further Information

Bioactivity:
Clomethiazole is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes.
CAS:
533-45-9
Formula:
C6H8ClNS
Molecular Weight:
161.65
Pathway:
Membrane transporter/Ion channel; Metabolism; Neuroscience
Purity:
0.9843
SMILES:
Cc1ncsc1CCCl
Target:
P45; GABA Receptor

References

1. Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.Eur J Pharmacol. 2002 Oct 11;452(3):255-62. 2. Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44(8):1424-30